Secret Squirrel

Rules: Played as normal, but each player's low down card, and all others of that rank in his hand, count as wild cards for him. (So if your low down card is a 7, all 7s in your hand are wild.) Common Variation: if the dealer declares it in advance, you may pay 50 cents in order to receive your last card face-up.
Analysis: With everyone guaranteed at least one wild card, and two being common, this usually falls to at least a boat. Four of a kind is common, and five of a kind not terribly rare.

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Variants

Canary in a Coal Mine: Like Secret Squirrel, but you get to roll all your face-up cards. Last card is always down.
Moose and Squirrel: Like Secret Squirrel, but if you have a visible pair you don't get any wild cards.
Speedy Gonzales: Mexican Sweat meets Secret Squirrel. 6 card no-peek; your low rank is wild for you.
That is: deal six cards face-down to each player. Don't look at your cards. Flip the top card of the deck, and play Mexican Sweat as usual. However, in the final showdown, your lowest rank is wild for you only, similar to Secret Squirrel.